Dissolution Testing and Rheological Characterization of Medicated Chewing Gums
Emmace Consulting AB offers dissolution testing of medicated chewing gums as an analytical service to clients on a CRO basis. The testing is performed according to Eur. Pharmacopoeia 2.9.25, using Apparatus B (three-cell model). We can implement methods already developed by the client, but we also offer the development of an assay method if one is not available. We have standard methods available for testing Nicotine chewing gums. The extent of the analytical test plan is always planned together with the client.
We can also measure rheological properties of the chewing gum during the dissolution testing. These measurements are possible because of the in-built sensors in one of the test cells; one sensor is measuring the force to press together the “jaws” and the other sensor is measuring the torque forces when the “jaws” are shearing the gum. These rheological data can be used as a fingerprint and indication of the “chewing feeling” of a gum, whether it is perceived by the consumer as soft and wet or as hard and compact. This information is important input to formulators so that the desired chewing feeling for the consumer can be achieved.