Selection of useful publications

AH de Boer, K Thalberg. Chapter 3: Devices and formulations: general introduction and wet aerosol delivery systems. In Inhaled Medicines: Optimizing Development Through Integration of In Silico, In Vitro and In Vivo Approaches (Eds. Hickey AJ, Kassinos S, Bäckman P, Conway J). Elsevier (academic Press Inc), 2021a ISBN-13: 9780128149744

AH de Boer, K Thalberg. Chapter 4: Metered Dose Inhalers (MDIs). In Inhaled Medicines: Optimizing Development Through Integration of In Silico, In Vitro and In Vivo Approaches (Eds. Hickey AJ, Kassinos S, Bäckman P, Conway J). Elsevier (academic Press Inc), 2021b ISBN-13: 9780128149744

AH de Boer, K Thalberg. Chapter 5: Dry Powder Inhalers (DPIs). In Inhaled Medicines: Optimizing Development Through Integration of In Silico, In Vitro and In Vivo Approaches (Eds. Hickey AJ, Kassinos S, Bäckman P, Conway J). Elsevier (academic Press Inc), 2021c ISBN-13: 9780128149744

B Olsson, H Lundbäck, M Svensson. Chapter 6: In vitro methods to study dose deposition. In Inhaled Medicines: Optimizing Development Through Integration of In Silico, In Vitro and In Vivo Approaches (Eds. Hickey AJ, Kassinos S, Bäckman P, Conway J). Elsevier (academic Press Inc), 2021 ISBN-13: 9780128149744

A Himstedt, P Bäckman, JM Borghardt. Chapter 12: Physiology-based pharmacokinetic modelling after drug inhalation. In Inhaled Medicines: Optimizing Development Through Integration of In Silico, In Vitro and In Vivo Approaches (Eds. Hickey AJ, Kassinos S, Bäckman P, Conway J). Elsevier (academic Press Inc), 2021 ISBN-13: 9780128149744

B Olsson and SC Kassinos, On the Validation of Generational Lung Deposition Computer Models Using Planar Scintigraphic Images: The Case of Mimetikos Preludium, J Aerosol Med Pulm Drug Deliv.2020; Ahead of print: https://doi-org.ludwig.lub.lu.se/10.1089/jamp.2020.1620

P Bäckman and B Olsson, “Pulmonary Drug Dissolution, Regional Retention & Systemic Absorption: Understanding their Interactions Through Mechanistic Modeling”, in Respiratory Drug Delivery 2020″

PG Koullapis, FS Stylianou, J Sznitman, B Olsson and SC Kassinos, “Towards whole-lung simulations of aerosol deposition: A model of the deep lung”, J Aerosol Sci. 2020; 144 105541,https://doi.org/10.1016/j.jaerosci.2020.105541

Coating Stages of Next Generation Impactor (NGI) When Testing Metered Dose Inhalers (MDIs) A Comparative Study on US Commercial MDI Products
Sandell D, Svensson M, Conti DS, Sheth P, Oguntimein O, Bielski E, Bulitta JB, Hochhaus G. Respiratory Drug Delivery 2020. Volume 2, 2020: 463-468.

Effects of Formulation and Actuator Design on Spray Pattern and Plume Geometry of Mometasone Furoate Metered Dose Inhalers
Dhapare S, Bielski E, Conti DS, Oguntimein O, Sheth P, Hallinger M, Svensson M, Sandell D, Bulitta JB, Hochhaus G. Respiratory Drug Delivery 2020. Volume 3, 2020: 503-508.

The Effects of Formulation Factors and Actuator Design on Mometasone Furoate Metered Dose Inhaler In Vitro Aerosolization Performance Bielski E, Conti DS, Oguntimein O, Sheth P, Hallinger M, Svensson M, Sandell D, Bulitta JB, Hochhaus G Respiratory Drug Delivery 2020. Volume 3, 2020: 497-502.

Nicholas, M., Josefsson, M., Fransson, M., Thalberg, K., Wilbs, J., Roos, C., Boissier, C., 2020. Quantification of surface concentration and surface structure of inhalation powders using TOF-SIMS. International Journal of Pharmaceutics 587, 119666.

Thalberg, K., Papathanasiou, F., Fransson, M., Nicholas, M., 2020. Controlling the performance of adhesive mixtures for inhalation using mixing energy. International Journal of Pharmaceutics 120055.

PG Koullapis, B Olsson, SC Kassinos and J Sznitman, “Multiscale in silico lung modeling strategies for aerosol inhalation therapy and drug delivery”, Curr Opin Biomed Eng. 2019; 11(September): 130-136

B Olsson and P Bäckman, Mimetikos PreludiumTM: A New Pharma-friendly Aerosol Drug Deposition Calculator, in Respiratory Drug Delivery 2018 (Eds. RN Dalby, PR Byron, D Traini, SJ Farr, JD Suman and A Watts), ISBN 978-1-942911-25-8, Virginia Commonwealth University, 2018, p 103-111

P Bäckman and B Olsson, “De-risking Inhalation Product Development using Predictive Models” in “Respiratory Drug Delivery Asia 2018”

P Bäckman, S Arora, W Couet, B Forbes, W de Kruijf, A Paudel. Advances in experimental and mechanistic computational models to understand pulmonary exposure to inhaled drugs. Eur J Pharm Sci. 2018 Feb 15;113:41-52. doi: 10.1016/j.ejps.2017.10.030.

Estimation of Stage Cut-offs for the Next Generation Impactor When Used at Flow Rates Above 100 L/min
Sandell D, Svensson M, Sandell K, Olsson A Respiratory Drug Delivery 2018. Volume 2, 2018: 513-518.

J Eriksson, E Sjögren, H Thörn, K Rubin, P Bäckman, H Lennernäs. Pulmonary absorption – estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex-vivo rat model and computational analysis, Eur J Pharm Biopharm. 2018 Mar; 124:1-12.

Nguyen, D., Remmelgas, J., Niklasson Björn, I., van Wachem, B., Thalberg, K, 2018. Towards quantitative prediction of the performance of dry powder inhalers by multi-scale simulations and experiments. International Journal of Pharmaceutics 547, 31-43.

Pressurized Metered Dose Inhalers and the Slow Inhalation Recommendation
Asking L, Olsson B, Berg E, Svensson M Respiratory Drug Delivery 2018. Volume 2, 2018: 463-466.

D Sandell, B Olsson and L Borgström, PK bioequivalence testing when between-batch variability is high: A multiple.batch proposal, Inhalation magazine 2017, December issue.

Svensson M, Berg E, Mitchell J, Sandell D. Laboratory Study Comparing Pharmacopeial Testing of Nebulizers with Evaluation Based on Nephele Mixing Inlet Methodology. AAPS PharmSciTech. 2018 Feb;19(2):565-572. doi: 10.1208/s12249-017-0860-8. Epub 2017 Sep 5. PMID: 28875453.

Thalberg, K., Åslund, S., Skogevall, M., Andersson, P., 2016. Dispersibility of lactose fines as compared to API in dry powders for inhalation. International Journal of Pharmaceutics 504, 27-38.

Thalberg, K., Berg, E., Fransson, M., 2012. Modeling dispersion of dry powders for inhalation. The concepts of total fines, cohesive energy and interaction parameters. International Journal of Pharmaceutics 427, 224-233.

B Olsson, L Borgström, M Svensson and H Lundbäck, Validation of a General In Vitro Approach for Prediction of Total Lung Deposition in Healthy Adults for Pharmaceutical Inhalation Products, J Aerosol Med Pulm Drug Deliv. 2013; 23: 355-369