A recent study by researchers at RISE and Emmace Consulting (Adj Prof Kyrre Thalberg), published in Surface and Interface Analysis, explores the molecular 3D distribution of budesonide and magnesium stearate (Mg-stearate) in dry powder inhalation formulations. Using advanced ToF-SIMS imaging and XPS analysis, the study reveals that lactose carrier particles are largely covered by a thin Mg-stearate coating (~5 nm thick), which moreover tend to coat the active drug particles. An appropriate coating layer is crucial for improving the dispersibility of inhalation powders, and hence for optimizing drug delivery to the lungs.

By visualizing the structural arrangement of components, the findings enhance understanding of adhesive mixture formulations, aiding in the development of more effective inhalable medications. The study highlights the value of 3D molecular characterization in pharmaceutical formulation research.

For more details, access the full publication here.