Laser Diffraction Testing (ISO 13320): Real-Time Aerosol & Droplet Sizing
Accelerate your formulation and device development with rapid, real-time droplet size characterization and inhalation expertise.
Understanding the dynamic particle and droplet size distribution of your aerosolized drug product is fundamental to predicting pulmonary and nasal deposition. ISO 13320 provides the international standard for particle size analysis via laser diffraction methods.
At Emmace, we use high-speed laser diffraction instrumentation—such as the Malvern Spraytec—to capture real-time, droplet size distributions across single spray events. Whether you are developing nasal sprays, soft mist inhalers (SMIs), nebulizers, pMDIs, or dry powder inhalers, our lab delivers the scientific precision needed for successful R&D and regulatory submissions.
Comprehensive ISO 13320 Testing Services
We combine state-of-the-art optical measurement with deep inhalation expertise, offering an agile, uncomplicated testing partnership:- Real-Time Droplet & Particle Sizing: Rapidly measure droplet/particle size distributions (D10, D50, D90, and Span) with millisecond temporal resolution during the actuation cycle.
- Phase-Selected Plume Analysis: Characterize droplet size changes across different phases of the actuation event (formation, fully developed spray, and dissipation) to ensure consistent device performance.
- Cross-Device Capability: Customized testing setups tailored for nasal devices, nebulizers, pMDIs, SMIs, and dry powder inhalers (DPIs).
- Rapid Formulations & Device Screening: Utilize laser diffraction as a fast, high-throughput screening tool to evaluate prototype devices and candidate formulations before proceeding to cascade impactor testing.
Bridging Laser Diffraction and Cascade Impaction
While laser diffraction (ISO 13320) measures physical droplet size in real time, regulatory authorities often require chemical quantification via Cascade Impaction (APSD).
As world leaders in aerosol characterization, Emmace helps you bridge the gap between optical droplet sizing and aerodynamic particle size distribution. By correlating laser diffraction data with our specialized rAPSD and cascade impactor methods, we provide a complete performance profile of your inhalation product. Read more about rAPSD here.
Senior Advisory: Translating Optics into Actionable Insights
Laser diffraction generates complex, high-density data files. Interpreting beam steering, multiple scattering, and refractive index parameters require specialized inhalation knowledge.
If you are interested in the emptying process of an inhaler? More information here.