Anatomical throat models – OPC throat models

Emmace Consulting offer an anatomical throat concept that enhance the prediction of the in-vivo properties and behavior of inhalation products.

Anatomical throat models OPC throat models
Anatomical throat models OPC throat models
anatomical throats

Our anatomically realistic throat models

Three anatomical throat models (small, medium, and large) were developed by a consortium (OPC) consisting of AstraZeneca, GlaxoSmithKline and sanofiaventis1. The geometry of the models originate from MRI studies of adults oropharynx part at inhalation maneuver and the three models were selected based on their dose filtering properties performed on different products (pMDI, DPI and Nebulizer). In vitro in vivo correlation (IVIVC) studies2 showed later on that the dose that passes these throat models correlated with the lung dose that was found in in vivo lung deposition studies. Moreover, by analyzing and comparing the aerosol doses that survive the small and the large throat models, the “lung dose” variability in an adult population can be estimated. The throat models can be used with cascade impactors, laser diffraction instruments, particle counters or combined with an integral filter downstream the model, which offers a case by case flexibility. These throat models are commercially available to the inhalation community by Emmace.

1)  https://doi.org/10.1089/jam.2007.0566

2) http://online.liebertpub.com/doi/abs/10.1089/jamp.2012.0986

Analytical testing using anatomical throat models

Emmace also offers analytical testing using these throats as a service on a CRO basis.

Emmace also offers advise regarding the analytical testing.

Please contact us if you are interested to receive a quote.

By analyzing the aerosol dose that passes through the anatomical models during inhalation experiment, the following investigations can be performed, 

  • Combination of the three throat models with a set of clinically relevant flow profiles gives a good prediction of how your inhalation product will behave in a clinical situation.
  • Inhaler handling robustness testing – predicts the effect on lung dose of inhaler vs. e.g., mouth position angle, distance from tongue position, or dose loading procedure.
  • Predict the effect on lung dose from add-on devices to inhalers, such as spacers.
  • Data from anatomical throat models are useful input when designing clinical studies, including selection of dose strength and number of doses. Data from OPC throat testing can also be used for understand clinical data that are “unexpected”.
  • Excellent screening tool in your daily development work; rank different device prototypes or formulation concepts by simply measure the dose that survives the models using a single filter downstream the throat model.
  • Compare your product/prototype versus competitors or reference products on the market.
  • Scientific marketing of your inhaler and formulation concept.
  • The anatomical throat models are manufactured according to the data from the OPC work and are made as single solid bodies, which reduces the risk for leakages of both air and solubilized drug. Customized adapters for inhaler adaptation, are manufactured upon request.

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