Development and Understanding of Dry Powder Formulations for Inhalation
Expert Guidance in Dry Powder Formulation Development
Our expert, Senior Inhalation Adviser Kyrre Thalberg, has published several peer reviewed articles and book chapters in this field, and manages the Development and Understanding of Dry Powder Formulations for Inhalation at Emmace.
Adj. Prof. Kyrre Thalberg holds a position as Adjunct Professor at Lund University, Sweden. Read more below.
At Emmace, we pride ourselves on offering unparalleled
expertise and guidance throughout the entire drug
product development process. Here’s how we can
elevate your project:
Early Stage – Product and Process Design
- Tailored Formulation Design: Aligning your formulation with the Target Product Profile (TPP).
- Raw Material Selection: Choosing the appropriate ingredients.
- Innovative Mixing Energy Concept: Identifying formulation sweet spots and predictable performance.
- Lactose Fines Optimization: Perfecting the content for enhanced performance.
- Advanced Coating Techniques: Utilizing agents like Mg-Stearate for improved robustness.
Process Development and Scale-Up
- Expert Scale-Up Strategies: Providing
actionable recommendations for seamless scale-up. - Adaptive Formulation Adjustments: Addressing potential changes and reformulation needs.
- Quality by Design (QbD): Implementing QbD and In-Process Controls (IPC) to ensure the right dispersibility and consistent quality.
Late-Stage Development
- Streamlined Manufacturing Processes: Simplifying and optimizing your production methods.
- Comprehensive IPC Strategies: Ensuring necessity and effectiveness in every step.
Additional Services
- In-Depth Reviews and Second Opinions: Thorough inspection and validation of your formulation development data.
- Due Diligence Studies: Expert judgment on the quality and reliability of your dry powder development data.
- Specialized Experimental Studies: Conducting advanced studies using techniques like AFM, TOF-SIMS, SEM-EDX, and XPS.
- Regulatory Support: Assisting with dossier reviews and regulatory authority interactions.
Kyrre Thalberg, PhD
Senior Adviser – Inhalation Product Development | Adjunct Professor – Department of Food Technology, Engineering and Nutrition, Lund University
For almost 30 years, Dr. Thalberg has worked in the field of dry powders for inhalation with AstraZeneca. He has been working with most kinds of dry powder formulation systems and have provided key contributions to a range of successful AZ inhalation products, for instance the Turbuhaler product family.
The toolbox of skills around dry powder inhalers contains selection of raw materials, their compositions and manufacturing processes, and well as physical characterization of formulations (material science), which includes different types of particle size analysis, bulk density and flowability assessment.
Moreover, Dr. Thalberg has also worked on development strategies for inhalation products, involving in depth understanding of critical parameters as well as modelling and simulation of the performance of dry powder inhalers.
Dr. Thalberg is MSc in chemical engineering and PhD in Physical Chemistry with focus on polymers and surfactants (Lund University 1990), and has authored and co-authored approximately 40 publications, whereof 20 are in the field of dry powder inhalation.
